Altered Resting-State Functional Connectivity of the Striatum in Parkinson's Disease after Levodopa Administration.

ABSTRACT:

Background

Despite improvement in motor symptoms, the effect of dopaminergic medications on cognition in patients with Parkinson's disease (PD) is less clear. The purpose of this study was to reveal levodopa-induced acute changes in the functional connectivity of the striatum in patients with PD compared with matched untreated patients and healthy volunteers.

Methods

Twenty-two patients with PD underwent functional magnetic resonance imaging both ON and OFF dopamine-replacement therapy on two consecutive days. Twenty-eight normal aging volunteers also did them without taking in levodopa. Three caudate seeds and two putamen seeds were selected to calculate functional connectivity intensity.

Results

Motor symptoms measured by UPDRS were significantly worse in PD OFF tha

SUBMITTER: Yang W 

PROVIDER: S-EPMC5017636 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature