Systemic Delivery and Biodistribution of Cisplatin in Vivo.

ABSTRACT: Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin's off-target effects, a new drug-fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration.

SUBMITTER: Chu YH 

PROVIDER: S-EPMC5017860 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature