Childhood Adversity, Self-Esteem, and Diurnal Cortisol Profiles Across the Life Span.

ABSTRACT: Childhood adversity is associated with poor health outcomes in adulthood; the hypothalamic-pituitary-adrenal (HPA) axis has been proposed as a crucial biological intermediary of these long-term effects. Here, we tested whether childhood adversity was associated with diurnal cortisol parameters and whether this link was partially explained by self-esteem. In both adults and youths, childhood adversity was associated with lower levels of cortisol at awakening, and this association was partially driven by low self-esteem. Further, we found a significant indirect pathway through which greater adversity during childhood was linked to a flatter cortisol slope via self-esteem. Finally, youths who had a caregiver with high self-esteem experienced a steeper decline in cortisol throughout the day co

SUBMITTER: Zilioli S 

PROVIDER: S-EPMC5017903 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature