Spindle Size Scaling Contributes to Robust Silencing of Mitotic Spindle Assembly Checkpoint.

ABSTRACT: Chromosome segregation during mitosis hinges on proper assembly of the microtubule spindle that establishes bipolar attachment to each chromosome. Experiments demonstrate allometry of mitotic spindles and a universal scaling relationship between spindle size and cell size across metazoans, which indicates a conserved principle of spindle assembly at play during evolution. However, the nature of this principle is currently unknown. Researchers have focused on deriving the mechanistic underpinning of the size scaling from the mechanical aspects of the spindle assembly process. In this work we take a different standpoint and ask: What is the size scaling for? We address this question from the functional perspectives of spindle assembly checkpoint (SAC). SAC is the critical surveillance mechan

SUBMITTER: Chen J 

PROVIDER: S-EPMC5018141 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature