Dataset Information
Combenefit: an interactive platform for the analysis and visualization of drug combinations.
Ontology highlight
ABSTRACT: Motivation
Many drug combinations are routinely assessed to identify synergistic interactions in the attempt to develop novel treatment strategies. Appropriate software is required to analyze the results of these studies.Results
We present Combenefit, new free software tool that enables the visualization, analysis and quantification of drug combination effects in terms of synergy and/or antagonism. Data from combinations assays can be processed using classical Synergy models (Loewe, Bliss, HSA), as single experiments or in batch for High Throughput Screens. This user-friendly tool provides laboratory scientists with an easy and systematic way to analyze their data. The companion package provides bioinformaticians with critical implementations of routines enabling the processing of combination data.Availability and implementation
Combenefit is provided as a Matlab package but also as standalone software for Windows (http://sourceforge.net/projects/combenefit/).Contact
Giovanni.DiVeroli@cruk.cam.ac.ukSupplementary information
Supplementary data are available at Bioinformatics online.
SUBMITTER: Di Veroli GY
PROVIDER: S-EPMC5018366 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Combenefit: an interactive platform for the analysis and visualization of drug combinations.
Bioinformatics (Oxford, England) 20160425 18
<h4>Motivation</h4>Many drug combinations are routinely assessed to identify synergistic interactions in the attempt to develop novel treatment strategies. Appropriate software is required to analyze the results of these studies.<h4>Results</h4>We present Combenefit, new free software tool that enables the visualization, analysis and quantification of drug combination effects in terms of synergy and/or antagonism. Data from combinations assays can be processed using classical Synergy models (Loe ...[more]