Weighted mutual information analysis substantially improves domain-based functional network models.

ABSTRACT:

Motivation

Functional protein-protein interaction (PPI) networks elucidate molecular pathways underlying complex phenotypes, including those of human diseases. Extrapolation of domain-domain interactions (DDIs) from known PPIs is a major domain-based method for inferring functional PPI networks. However, the protein domain is a functional unit of the protein. Therefore, we should be able to effectively infer functional interactions between proteins based on the co-occurrence of domains.

Results

Here, we present a method for inferring accurate functional PPIs based on the similarity of domain composition between proteins by weighted mutual information (MI) that assigned different weights to the domains based on their genome-wide frequencies. Weighted MI outperforms other doma

SUBMITTER: Shim JE 

PROVIDER: S-EPMC5018372 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature