Vitamin K Antagonists and Cognitive Function in Older Adults: The Three-City Cohort Study.

ABSTRACT:

Background

A growing body of evidence supports a beneficial role for vitamin K in brain and cognition, notably in studies where animals are rendered vitamin K deficient by warfarin, a potent vitamin K antagonist (VKA). Given VKAs are commonly used oral anticoagulants in older persons, we investigated the relationship between VKA therapy and cognitive performances over 10 years in participants of the Three-City study.

Methods

The Three-City cohort included 7,133 nondemented community dwellers, aged 65 years or older at baseline. Exposures to VKAs and platelet aggregation inhibitors, another antithrombotic agent, were determined at baseline. Participants underwent cognitive assessment at baseline and every 2 years over 10 years. Associations were analyzed with mixed linear mod

SUBMITTER: Ferland G 

PROVIDER: S-EPMC5018559 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature