Vitamin K Status and Lower Extremity Function in Older Adults: The Health Aging and Body Composition Study.

ABSTRACT:

Background

While low vitamin K status has been associated with several chronic diseases that can lead to lower extremity disability, it is not known if low vitamin K status is associated with worse lower extremity function.

Methods

Vitamin K status was measured according to plasma phylloquinone (vitamin K1) and dephosphorylated-uncarboxylated MGP (dp-ucMGP) in 1,089 community-dwelling older adults (mean ± SD age =74±3 years; 67% female). Lower extremity function was assessed using the short physical performance battery (SPPB), gait speed, and isokinetic leg strength. Linear regression and mixed models were used to determine the cross-sectional and longitudinal associations between vitamin K status and functional outcome measures.

Results

Cross-sectionally, higher plas

SUBMITTER: Shea MK 

PROVIDER: S-EPMC5018560 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature