Age-dependent effects of APOE ε4 in preclinical Alzheimer's disease.

ABSTRACT:

Objective

The ε4 allele of apolipoprotein E (APOE) is the strongest known common genetic risk factor for Alzheimer's disease (AD) and alters age of onset in retrospective studies. Here, we longitudinally test the effects of APOE ε4 genotype and age during progression from normal cognition to AD.

Methods

Using data from 5381 cognitively normal older individuals and Cox proportional hazards models, we longitudinally tested the effects of APOE genotype on progression from normal cognition to mild cognitive impairment (MCI) or AD in four age strata (<60, 60-70, 70-80, 80 + ) and with a sliding window approach between ages 60 and 85.

Results

We found that APOE ε4 carrier status and dosage significantly influenced progression to MCI or AD in all four age groups and that APO

SUBMITTER: Bonham LW 

PROVIDER: S-EPMC5018579 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature