Interplay of brain structure and function in neonatal congenital heart disease.

ABSTRACT:

Objective

To evaluate whether structural and microstructural brain abnormalities in neonates with congenital heart disease (CHD) correlate with neuronal network dysfunction measured by analysis of EEG connectivity.

Methods

We studied a prospective cohort of 20 neonates with CHD who underwent continuous EEG monitoring before surgery to assess functional brain maturation and network connectivity, structural magnetic resonance imaging (MRI) to determine the presence of brain injury and structural brain development, and diffusion tensor MRI to assess brain microstructural development.

Results

Neonates with MRI brain injury and delayed structural and microstructural brain development demonstrated significantly stronger high-frequency (beta and gamma frequency band) connect

SUBMITTER: Birca A 

PROVIDER: S-EPMC5018583 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature