Osteogenic differentiation of preosteoblasts on a hemostatic gelatin sponge.

ABSTRACT: Bone tissue engineering provides many advantages for repairing skeletal defects. Although many different kinds of biomaterials have been used for bone tissue engineering, safety issues must be considered when using them in a clinical setting. In this study, we examined the effects of using a common clinical item, a hemostatic gelatin sponge, as a scaffold for bone tissue engineering. The use of such a clinically acceptable item may hasten the translational lag from laboratory to clinical studies. We performed both degradation and biocompatibility studies on the hemostatic gelatin sponge, and cultured preosteoblasts within the sponge scaffold to demonstrate its osteogenic differentiation potential. In degradation assays, the gelatin sponge demonstrated good stability after being immersed in

SUBMITTER: Kuo ZK 

PROVIDER: S-EPMC5018723 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature