Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β.

ABSTRACT: Traditional fragment-based drug discovery (FBDD) relies heavily on structural analysis of the hits bound to their targets. Herein, we present a complementary approach based on diversity-oriented synthesis (DOS). A DOS-based fragment collection was able to produce initial hit compounds against the target GSK3β, allow the systematic synthesis of related fragment analogues to explore fragment-level structure-activity relationship, and finally lead to the synthesis of a more potent compound.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5018862 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature