Association of Progressive Cerebellar Atrophy With Long-term Outcome in Patients With Anti-N-Methyl-d-Aspartate Receptor Encephalitis.

ABSTRACT:

Importance

Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is an immune-mediated disorder that occurs with IgG antibodies against the GluN1 subunit of NMDAR. Some patients develop reversible diffuse cerebral atrophy (DCA), but the long-term clinical significance of progressive brain and cerebellar atrophy is unknown.

Objective

To report the long-term clinical implications of DCA and cerebellar atrophy in anti-NMDAR encephalitis.

Design, setting, and participants

A retrospective observational study and long-term imaging investigation was conducted in the Department of Neurology at Kitasato University. Fifteen patients with anti-NMDAR encephalitis admitted to Kitasato University Hospital between January 1, 1999, and December 31, 2014, were included; data analysi

SUBMITTER: Iizuka T 

PROVIDER: S-EPMC5018902 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature