Pluronic^® P123/F127 mixed micelles delivering sorafenib and its combination with verteporfin in cancer cells.

ABSTRACT: Here, we developed Pluronic^® P123/F127 (poloxamer) mixed micelles for the intravenous delivery of the anticancer drug sorafenib (SRB) or its combination with verteporfin (VP), a photosensitizer for photodynamic therapy that should complement well the cytotoxicity profile of the chemotherapeutic. SRB loading inside the core of micelles was governed by the drug:poloxamer weight ratio, while in the case of the SRB-VP combination, a mutual interference between the two drugs occurred and only specific ratios could ensure maximum loading efficiency. Coentrapment of SRB did not alter the photophysical properties of VP, confirming that SRB did not participate in any bimolecular process with the photosensitizer. Fluorescence resonance energy-transfer measurement of micelles in serum prot

SUBMITTER: Pellosi DS 

PROVIDER: S-EPMC5019320 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature