DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions.

ABSTRACT: Dengue virus (DENV) is a human pathogen and its etiology has been widely established. There are many interactions between DENV and human proteins that have been reported in literature. However, no publicly accessible resource for efficiently retrieving the information is yet available. In this study, we mined all publicly available dengue-human interactions that have been reported in the literature into a database called DenHunt. We retrieved 682 direct interactions of human proteins with dengue viral components, 382 indirect interactions and 4120 differentially expressed human genes in dengue infected cell lines and patients. We have illustrated the importance of DenHunt by mapping the dengue-human interactions on to the host interactome and observed that the virus targets multiple host f

SUBMITTER: Karyala P 

PROVIDER: S-EPMC5019383 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature