Artificial Diiron Enzymes with a De Novo Designed Four-Helix Bundle Structure.

ABSTRACT: A single polypeptide chain may provide an astronomical number of conformers. Nature selected only a trivial number of them through evolution, composing an alphabet of scaffolds, that can afford the complete set of chemical reactions needed to support life. These structural templates are so stable that they allow several mutations without disruption of the global folding, even having the ability to bind several exogenous cofactors. With this perspective, metal cofactors play a crucial role in the regulation and catalysis of several processes. Nature is able to modulate the chemistry of metals, adopting only a few ligands and slightly different geometries. Several scaffolds and metal-binding motifs are representing the focus of intense interest in the literature. This review discusses the wi

SUBMITTER: Chino M 

PROVIDER: S-EPMC5019575 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature