Baseline Prostate-Specific Antigen Levels in Midlife Predict Lethal Prostate Cancer.

ABSTRACT:

Purpose

Prostate-specific antigen (PSA) level in midlife predicted future prostate cancer (PCa) mortality in an unscreened Swedish population. Our purpose was to determine if a baseline PSA level during midlife predicts lethal PCa in a US population with opportunistic screening.

Materials and methods

We conducted a nested case-control study among men age 40 to 59 years who gave blood before random assignment in the Physicians' Health Study, a randomized, placebo-controlled trial of aspirin and β-carotene among 22,071 US male physicians initiated in 1982 and then transitioned into a prospective cohort with 30 years of follow-up. Baseline PSA levels were available for 234 patients with PCa and 711 age-matched controls. Seventy-one participants who developed lethal PCa were rem

SUBMITTER: Preston MA 

PROVIDER: S-EPMC5019757 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature