Genetic association of Toll-like receptor 4 gene and coronary artery disease in a Chinese Han population.

ABSTRACT:

Purpose

Toll-like receptor 4 (TLR4) is known to be involved in innate immunity and inflammatory responses that play important roles in the pathogenesis of coronary artery disease (CAD). But the relationship between TLR4 gene and CAD has yet to be investigated. The present study aimed to evaluate the association of TLR4 gene polymorphisms with CAD susceptibility in a Chinese Han population.

Methods

A total of 1094 subjects (577 unrelated patients with CAD and 517 controls) were recruited between 2008 and 2012. Three tag SNPs (rs1927907, rs1927911 and rs11536889) present in the TLR4 gene were genotyped using Sequenom Mass-ARRAY system.

Results

The genotypic distributions of the three SNPs were not deviate from Hardy-Weinberg equilibrium. There was no significant differe

SUBMITTER: Zhou L 

PROVIDER: S-EPMC5019996 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature