Neospora caninum Activates p38 MAPK as an Evasion Mechanism against Innate Immunity.

ABSTRACT: Due to the high prevalence and economic impact of neosporosis, the development of safe and effective vaccines and therapies against this parasite has been a priority in the field and is crucial to limit horizontal and vertical transmission in natural hosts. Limited data is available regarding factors that regulate the immune response against this parasite and such knowledge is essential in order to understand Neospora caninum induced pathogenesis. Mitogen-activated protein kinases (MAPKs) govern diverse cellular processes, including growth, differentiation, apoptosis, and immune-mediated responses. In that sense, our goal was to understand the role of MAPKs during the infection by N. caninum. We found that p38 phosphorylation was quickly triggered in macrophages stimulated by live tachyzoi

SUBMITTER: Mota CM 

PROVIDER: S-EPMC5020094 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature