Regional and Gender Study of Neuronal Density in Brain during Aging and in Alzheimer's Disease.

ABSTRACT:

Background

Learning processes or language development are only some of the cognitive functions that differ qualitatively between men and women. Gender differences in the brain structure seem to be behind these variations. Indeed, this sexual dimorphism at neuroanatomical level is accompanied unequivocally by differences in the way that aging and neurodegenerative diseases affect men and women brains.

Objective

The aim of this study is the analysis of neuronal density in four areas of the hippocampus, and entorhinal and frontal cortices to analyze the possible gender influence during normal aging and in Alzheimer's disease (AD).

Methods

Human brain tissues of different age and from both sexes, without neurological pathology and with different Braak's stages of AD, were

SUBMITTER: Martinez-Pinilla E 

PROVIDER: S-EPMC5020132 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature