Clinical and Immunologic Investigations in Patients With Stiff-Person Spectrum Disorder.

ABSTRACT:

Importance

Symptoms of stiff-person syndrome (SPS), stiff-limb syndrome (SLS), or progressive encephalomyelitis with rigidity, myoclonus, or other symptoms (SPS-plus) can occur with several autoantibodies, but the relative frequency of each antibody, syndrome specificity, and prognostic implications are unclear.

Objective

To report the clinical and immunologic findings of a large cohort of patients with stiff-person spectrum disorder (SPSD), including SPS, SLS, and SPS-plus.

Design, setting, and patients

This study retrospectively examined a case series (January 1, 1998, through December 31, 2014) of immunologic investigations performed in a neuroimmunology referral center. The study included 121 patients with clinical features of SPSD. Data analysis was performed fro

SUBMITTER: Martinez-Hernandez E 

PROVIDER: S-EPMC5020136 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature