De novo sequencing, assembly and analysis of eight different transcriptomes from the Malayan pangolin.

ABSTRACT: Pangolins are scale-covered mammals, containing eight endangered species. Maintaining pangolins in captivity is a significant challenge, in part because little is known about their genetics. Here we provide the first large-scale sequencing of the critically endangered Manis javanica transcriptomes from eight different organs using Illumina HiSeq technology, yielding ~75 Giga bases and 89,754 unigenes. We found some unigenes involved in the insect hormone biosynthesis pathway and also 747 lipids metabolism-related unigenes that may be insightful to understand the lipid metabolism system in pangolins. Comparative analysis between M. javanica and other mammals revealed many pangolin-specific genes significantly over-represented in stress-related processes, cell proliferation and external stim

SUBMITTER: Mohamed Yusoff A 

PROVIDER: S-EPMC5020319 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature