Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium.

ABSTRACT:

Study objectives

Low or excessive sleep duration has been associated with multiple outcomes, but the biology behind these associations remains elusive. Specifically, genetic studies in children are scarce. In this study, we aimed to: (1) estimate the proportion of genetic variance of sleep duration in children attributed to common single nucleotide polymorphisms (SNPs), (2) identify novel SNPs associated with sleep duration in children, and (3) investigate the genetic overlap of sleep duration in children and related metabolic and psychiatric traits.

Methods

We performed a population-based molecular genetic study, using data form the EArly Genetics and Life course Epidemiology (EAGLE) Consortium. 10,554 children of European ancestry were included in the discovery, and 1,250

SUBMITTER: Marinelli M 

PROVIDER: S-EPMC5020368 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature