Utility of the dual-specificity protein kinase TTK as a therapeutic target for intrahepatic spread of liver cancer.

ABSTRACT: Therapies for primary liver cancer, the third leading cause of cancer-related death worldwide, remain limited. Following multi-omics analysis (including whole genome and transcriptome sequencing), we were able to identify the dual-specific protein kinase TTK as a putative new prognostic biomarker for liver cancer. Herein, we show that levels of TTK protein are significantly elevated in neoplastic tissues from a cohort of liver cancer patients, when compared with adjacent hepatic tissues. We also tested the utility of TTK targeted inhibition and have demonstrated therapeutic potential in an experimental model of liver cancer in vivo. Following lentiviral shRNA knockdown in several human liver cancer cell lines, we demonstrated that TTK boosts cell growth and promotes cell spreading; as well

SUBMITTER: Miao R 

PROVIDER: S-EPMC5020615 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature