Effect of inhaled corticosteroids on blood eosinophil count in steroid-naive patients with COPD.

ABSTRACT:

Introduction

Sputum and blood eosinophil counts have attracted attention as potential biomarkers in chronic obstructive pulmonary disease (COPD). One question regarding the use of blood eosinophils as a biomarker in COPD is whether their levels are affected by the use of inhaled corticosteroids (ICS), which are commonly prescribed for COPD.

Methods

We performed a retrospective analysis of peripheral blood leucocytes from a previously completed clinical trial that examined effects of ICS in steroid-naïve patients with COPD.

Results and conclusion

The data show that the ICS-containing treatment arms (containing fluticasone propionate) had a small effect on peripheral blood eosinophils in steroid-naïve patients with COPD.

Trial registration number

NCT00358358; Pos

SUBMITTER: Kreindler JL 

PROVIDER: S-EPMC5020662 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature