Lack of association between NCAM1 and early onset schizophrenia in a family based study in Shandong peninsula of China.

ABSTRACT: The neural cell adhesion molecule (NCAM1) gene plays important roles in cellular migration, synaptic integrity and neurodevelopment. Multiple NCAM1 proteins are differentially altered in schizophrenia (SZ). A whole genome association study was first carried out on Affymetrix genome-wide human single-nucleotide polymorphism (SNP) Array 6.0 and two pooled DNA samples consisting of 89 early onset SZ (EOS) cases and 1,000 controls. Association between rs10891495 and EOS was detected (χ(2) = 2 3.66, P = 1.15E-06). The position of this SNP is just within the NCAM1 gene. Since several previous studies reported that NCAM1 was a candidate gene for SZ, we further performed a family based association study and genotyped six SNPs (rs10891495, rs1245133, rs1821693, rs686050, rs12794326, rs674246) withi

SUBMITTER: Chen X 

PROVIDER: S-EPMC5020918 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature