The BioFIND study: Characteristics of a clinically typical Parkinson's disease biomarker cohort.

ABSTRACT:

Background

Identifying PD-specific biomarkers in biofluids will greatly aid in diagnosis, monitoring progression, and therapeutic interventions. PD biomarkers have been limited by poor discriminatory power, partly driven by heterogeneity of the disease, variability of collection protocols, and focus on de novo, unmedicated patients. Thus, a platform for biomarker discovery and validation in well-characterized, clinically typical, moderate to advanced PD cohorts is critically needed.

Methods

BioFIND (Fox Investigation for New Discovery of Biomarkers in Parkinson's Disease) is a cross-sectional, multicenter biomarker study that established a repository of clinical data, blood, DNA, RNA, CSF, saliva, and urine samples from 118 moderate to advanced PD and 88 healthy control subj

SUBMITTER: Kang UJ 

PROVIDER: S-EPMC5021110 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature