Concise Review: Cell-Based Therapies and Other Non-Traditional Approaches for Type 1 Diabetes.

ABSTRACT: The evolution of Type 1 diabetes (T1D) therapy has been marked by consecutive shifts, from insulin replacement to immunosuppressive drugs and targeted biologics (following the understanding that T1D is an autoimmune disease), and to more disease-specific or patient-oriented approaches such as antigen-specific and cell-based therapies, with a goal to provide efficacy, safety, and long-term protection. At the same time, another important paradigm shift from treatment of new onset T1D patients to prevention in high-risk individuals has taken place, based on the hypothesis that therapeutic approaches deemed sufficiently safe may show better efficacy if applied early enough to maintain endogenous β cell function, a concept supported by many preclinical studies. This new strategy has been made p

SUBMITTER: Creusot RJ 

PROVIDER: S-EPMC5021120 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature