RNA-seq analysis of developing olfactory bulb projection neurons.

ABSTRACT: Transmission of olfactory information to higher brain regions is mediated by olfactory bulb (OB) projection neurons, the mitral and tufted cells. Although mitral/tufted cells are often characterized as the OB counterpart of cortical projection neurons (also known as pyramidal neurons), they possess several unique morphological characteristics and project specifically to the olfactory cortices. Moreover, the molecular networks contributing to the generation of mitral/tufted cells during development are largely unknown. To understand the developmental patterns of gene expression in mitral/tufted cells in the OB, we performed transcriptome analyses targeting purified OB projection neurons at different developmental time points with next-generation RNA sequencing (RNA-seq). Through these analy

SUBMITTER: Kawasawa YI 

PROVIDER: S-EPMC5021293 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature