Identification of a New Benzimidazole Derivative as an Antiviral against Hepatitis C Virus.

ABSTRACT:

Unlabelled

Aminoquinolines and piperazines, linked or not, have been used successfully to treat malaria, and some molecules of this family also exhibit antiviral properties. Here we tested several derivatives of 4-aminoquinolines and piperazines for their activity against hepatitis C virus (HCV). We screened 11 molecules from three different families of compounds, and we identified anti-HCV activity in cell culture for six of them. Of these, we selected a compound (B5) that is currently ending clinical phase I evaluation for neurodegenerative diseases. In hepatoma cells, B5 inhibited HCV infection in a pangenotypic and dose-dependent manner, and its antiviral activity was confirmed in primary hepatocytes. B5 also inhibited infection by pseudoparticles expressing HCV envelope glycop

SUBMITTER: Vausselin T 

PROVIDER: S-EPMC5021404 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature