Genetic variants in microRNA and microRNA biogenesis pathway genes and breast cancer risk among women of African ancestry.

ABSTRACT: MicroRNAs (miRNA) regulate breast biology by binding to specific RNA sequences, leading to RNA degradation and inhibition of translation of their target genes. While germline genetic variations may disrupt some of these interactions between miRNAs and their targets, studies assessing the relationship between genetic variations in the miRNA network and breast cancer risk are still limited, particularly among women of African ancestry. We systematically put together a list of 822 and 10,468 genetic variants among primary miRNA sequences and 38 genes in the miRNA biogenesis pathway, respectively; and examined their association with breast cancer risk in the ROOT consortium which includes women of African ancestry. Findings were replicated in an independent consortium. Logistic regression was

SUBMITTER: Qian F 

PROVIDER: S-EPMC5021583 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature