Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity.

ABSTRACT:

Objective

A disturbed day-night rhythm is associated with metabolic perturbations that can lead to obesity and type 2 diabetes mellitus (T2DM). In skeletal muscle, a reduced oxidative capacity is also associated with the development of T2DM. However, whether oxidative capacity in skeletal muscle displays a day-night rhythm in humans has so far not been investigated.

Methods

Lean, healthy subjects were enrolled in a standardized living protocol with regular meals, physical activity and sleep to reflect our everyday lifestyle. Mitochondrial oxidative capacity was examined in skeletal muscle biopsies taken at five time points within a 24-hour period.

Results

Core-body temperature was lower during the early night, confirming a normal day-night rhythm. Skeletal muscle oxid

SUBMITTER: van Moorsel D 

PROVIDER: S-EPMC5021670 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature