Childhood Trauma and COMT Genotype Interact to Increase Hippocampal Activation in Resilient Individuals.

ABSTRACT: Both childhood trauma and a functional catechol-O-methyltransferase (COMT) genetic polymorphism have been associated with posttraumatic stress disorder (PTSD) and depression; however, it is still unclear whether the two interact and how this interaction relates to long-term risk or resilience. Imaging and genotype data were collected on 73 highly traumatized women. DNA extracted from saliva was used to determine COMT genotype (Val/Val, n = 38, Met carriers, n = 35). Functional MRI data were collected during a Go/NoGo task to investigate the neurocircuitry underlying response inhibition. Self-report measures of adult and childhood trauma exposure, PTSD and depression symptom severity, and resilience were collected. Childhood trauma was found to interact with COMT genotype to impact inhibiti

SUBMITTER: van Rooij SJ 

PROVIDER: S-EPMC5021680 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature