Contribution of Post-translational Phosphorylation to Sarcomere-Linked Cardiomyopathy Phenotypes.

ABSTRACT: Secondary shifts develop in post-translational phosphorylation of sarcomeric proteins in multiple animal models of inherited cardiomyopathy. These signaling alterations together with the primary mutation are predicted to contribute to the overall cardiac phenotype. As a result, identification and integration of post-translational myofilament signaling responses are identified as priorities for gaining insights into sarcomeric cardiomyopathies. However, significant questions remain about the nature and contribution of post-translational phosphorylation to structural remodeling and cardiac dysfunction in animal models and human patients. This perspective essay discusses specific goals for filling critical gaps about post-translational signaling in response to these inherited mutations, espec

SUBMITTER: Westfall MV 

PROVIDER: S-EPMC5021686 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature