Statin-induced myopathy in a usual care setting-a prospective observational study of gender differences.

ABSTRACT:

Purpose

The study aims to identify the occurrence and remission of statin-induced myopathy including patient perception and symptom characteristics with a gender perspective.

Methods

The study was designed as a prospective, non-interventional investigation in 192 outpatients receiving statin treatment in usual care with 12 months follow-up. Main outcome measure was myopathy related to statin treatment and classified as probable using WHO criteria for adverse drug reaction (ADR) assessment.

Results

Fourteen percent developed myopathy, risk ratio for women 1.52 [95 % CI 1.37; 1.66] as compared to men. The majority graded their pain as "severe." CK values were within normal range. Eighty percent of the women compared to 43 % of the men reported that the muscular symptoms

SUBMITTER: Skilving I 

PROVIDER: S-EPMC5021730 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature