Fecal metabolome of the Hadza hunter-gatherers: a host-microbiome integrative view.

ABSTRACT: The recent characterization of the gut microbiome of traditional rural and foraging societies allowed us to appreciate the essential co-adaptive role of the microbiome in complementing our physiology, opening up significant questions on how the microbiota changes that have occurred in industrialized urban populations may have altered the microbiota-host co-metabolic network, contributing to the growing list of Western diseases. Here, we applied a targeted metabolomics approach to profile the fecal metabolome of the Hadza of Tanzania, one of the world's few remaining foraging populations, and compared them to the profiles of urban living Italians, as representative of people in the post-industrialized West. Data analysis shows that during the rainy season, when the diet is primarily plant-b

SUBMITTER: Turroni S 

PROVIDER: S-EPMC5021991 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature