The frequency distribution of vitamin D Receptor fok I gene polymorphism among Ugandan pulmonary TB patients.

ABSTRACT: Background:Mycobacterium tuberculosis (TB) is still a major problem globally and especially in Africa. Vitamin D deficiency has been linked to TB in the past and studies have found vitamin D deficiency to be common among Ugandan TB patients. The functional activity of vitamin D is dependent on the genotype of the vitamin D receptor (VDR) polymorphic genes. Recent findings have indicated that VDR polymorphisms may cause increased resistance or susceptibility to TB. The vitamin D ligand and its receptor play a pivotal role in innate immunity by eliciting antimicrobial activity, which is important in prevention of TB. The fok I vitamin D receptor gene has extensively been examined in TB patients but findings so far have been inconclusive. Objectives: This study sou

SUBMITTER: Acen EL 

PROVIDER: S-EPMC5022702 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature