Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk.

ABSTRACT:

Objective

We sought to estimate the causal effect of low serum 25(OH)D on multiple sclerosis (MS) susceptibility that is not confounded by environmental or lifestyle factors or subject to reverse causality.

Methods

We conducted mendelian randomization (MR) analyses using an instrumental variable (IV) comprising 3 single nucleotide polymorphisms found to be associated with serum 25(OH)D levels at genome-wide significance. We analyzed the effect of the IV on MS risk and both age at onset and disease severity in 2 separate populations using logistic regression models that controlled for sex, year of birth, smoking, education, genetic ancestry, body mass index at age 18-20 years or in 20s, a weighted genetic risk score for 110 known MS-associated variants, and the presence of on

SUBMITTER: Rhead B 

PROVIDER: S-EPMC5022843 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature