An Investigator-initiated Study to Assess the Safety and Efficacy of Ingenol Mebutate 0.05% Gel When Used After Cryosurgery in the Treatment of Hypertrophic Actinic Keratosis on Dorsal Hands.

ABSTRACT:

Objectives

To evaluate the safety and efficacy of ingenol mebutate 0.05% gel after cryosurgery versus cryosurgery alone for the treatment of hypertrophic and nonhypertrophic actinic keratosis on the dorsal hands.

Design

Investigator-blinded split arm study.

Setting

Academic institution.

Participants

Sixteen subjects with actinic keratoses on dorsal hands.

Results

There was a mean reduction in the number of hypertrophic actinic keratosis lesions adjusted for baseline in ingenol mebutate-treated versus control group of -4.3 versus -2.8, respectively. There was a mean reduction in the number of non-hypertrophic actinic keratosis lesions in the ingenol mebutate-treated versus control group of -3.8 versus -0.3.

Conclusion

A statistically significant an

SUBMITTER: Hashim PW 

PROVIDER: S-EPMC5022999 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature