A Model of the Spatio-temporal Dynamics of Drosophila Eye Disc Development.

ABSTRACT: Patterning and growth are linked during early development and have to be tightly controlled to result in a functional tissue or organ. During the development of the Drosophila eye, this linkage is particularly clear: the growth of the eye primordium mainly results from proliferating cells ahead of the morphogenetic furrow (MF), a moving signaling wave that sweeps across the tissue from the posterior to the anterior side, that induces proliferating cells anterior to it to differentiate and become cell cycle quiescent in its wake. Therefore, final eye disc size depends on the proliferation rate of undifferentiated cells and on the speed with which the MF sweeps across the eye disc. We developed a spatio-temporal model of the growing eye disc based on the regulatory interactions controlled by

SUBMITTER: Fried P 

PROVIDER: S-EPMC5023109 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature