Live Observation of Atherosclerotic Plaque Disruption in Apolipoprotein E-Deficient Mouse.

ABSTRACT:

Aim

The actual occurrence of spontaneous plaque rupture in mice has been a matter of debate. We report on an in vivo observation of the actual event of possible plaque disruption in a living ApoE(-/-) mouse.

Methods and results

During live contrast-enhanced ultrasonography of a 50-week-old ApoE(-/-) male mouse, symptoms suggesting plaque disruption in the brachiocephalic artery were observed. Histological analysis confirmed the presence of advanced atherosclerotic lesions with dissections and intraplaque hemorrhage in the affected brachiocephalic trunk, pointing towards plaque rupture as the cause of the observed event. However, we did not detect a luminal thrombus or cap rupture, which is a key criterion for plaque rupture in human atherosclerosis.

Conclusion

This st

SUBMITTER: Daeichin V 

PROVIDER: S-EPMC5023208 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature