Synthesis, characterization, and application of polysodium N-alkylenyl α-d-glucopyranoside surfactants for micellar electrokinetic chromatography-tandem mass spectrometry.

ABSTRACT: Sugar-based ionic surfactants forming micelles are known to suppress ESI of various compounds due to decrease in surface tension upon micelle formation . For the first time, poly (sodium N-undecylenyl-α-d-glucopyranoside 4,6-hydrogen phosphate, (poly-α-d-SUGP) based surfactants with different chain lengths and head groups have been successfully synthesized, characterized, and applied as compatible chiral selector for MEKC-ESI-MS/MS. First, the effect of polymerization concentration of the monomer, α-d-SUGP, was evaluated by enantioseparation of one anionic compound (1,1'-binaphthyl-2,2'diyl-hydrogen phosphate) and one zwitterionic compound (dansylated phenylalanine) in MEKC-UV to find the optimum molar surfactant concentration for polymerization. Next, MEKC-UV and MEKC-MS were compared for

SUBMITTER: Liu Y 

PROVIDER: S-EPMC5023327 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature