Transcriptomic Segregation of Human Autoantigens Useful for the Diagnosis of Autoimmune Diseases.

ABSTRACT: The measurement of autoantibodies in the clinical care of autoimmune patients allows for diagnosis, monitoring, and even disease prediction. Despite their clinical utility, the functional significance of autoantibody target proteins in many autoimmune diseases remains unclear. Here we present a comprehensive review of 52 autoantigens commonly employed for the serological diagnosis of 24 autoimmune diseases. We discuss their function, whether they have extracellular-exposed epitopes, and whether antibodies to these proteins are known to be pathogenic. Transcriptomics (RNA-Seq) datasets were mined to display messenger RNA (mRNA) expression of the autoantigens across 32 tissues and organs. This analysis revealed that autoantigens cluster into one of three groups: expression in the tissue most

SUBMITTER: Burbelo PD 

PROVIDER: S-EPMC5023465 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature