Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance.

ABSTRACT: Beige adipocytes gained much attention as an alternative cellular target in anti-obesity therapy. While recent studies have identified a number of regulatory circuits that promote beige adipocyte differentiation, the molecular basis of beige adipocyte maintenance remains unknown. Here, we demonstrate that beige adipocytes progressively lose their morphological and molecular characteristics after withdrawing external stimuli and directly acquire white-like characteristics bypassing an intermediate precursor stage. The beige-to-white adipocyte transition is tightly coupled to a decrease in mitochondria, increase in autophagy, and activation of MiT/TFE transcription factor-mediated lysosome biogenesis. The autophagy pathway is crucial for mitochondrial clearance during the transition; inhibit

SUBMITTER: Altshuler-Keylin S 

PROVIDER: S-EPMC5023491 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature