Cutting off the power: inhibition of leukemia cell growth by pausing basal ATP release and P2X receptor signaling?

ABSTRACT: T cells respond to antigen stimulation with the rapid release of cellular ATP, which stimulates an autocrine feedback mechanism that regulates calcium influx through P2X receptors. This autocrine purinergic feedback mechanism plays an essential role in the activation of T cells resulting in cell proliferation and clonal expansion. We recently reported that increases in mitochondrial ATP production drive this stimulation-induced purinergic signaling mechanism but that low-level mitochondrial ATP production fuels basal T cell functions required to maintain vigilance of unstimulated T cells. Here we studied whether defects in these purinergic signaling mechanisms are involved in the unwanted proliferation of leukemia T cells. We found that acute leukemia T cells (Jurkat) possess a larger numb

SUBMITTER: Ledderose C 

PROVIDER: S-EPMC5023625 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature