Evaluation of a topical herbal patch for soft tissue wound healing: an animal study.

ABSTRACT:

Aim

This study evaluated the effects of a topical herbal patch (PerioPatch®) for gingival wound healing in a rat model.

Materials and methods

A mid-crestal incision was performed on each side of the edentulous anterior maxilla in 48, 6-month-old, Wistar rats. Full-thickness flaps were raised, repositioned and sutured. Four experimental groups were established: herbal patch, placebo patch, no patch and no patch and no surgery. Patches were placed immediately after surgery and replaced every 12 h for the following 3 days. Half of the animals were killed after 5 and the remaining ones after 12 days. Tissue blocks were retrieved and processed for histological and immunohistochemical evaluation. Epithelial gap, collagen contents, amount of macrophages, cellular proliferation and

SUBMITTER: Chaushu L 

PROVIDER: S-EPMC5024077 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature