CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model.

ABSTRACT: The centromere drive model explaining rapid evolution of eukaryotic centromeres predicts higher frequency of positive selection acting on centromeric histone H3 (CenH3) in clades with asymmetric meiosis compared to the clades with only symmetric meiosis. However, despite the impression one might get from the literature, this key prediction of the centromere drive model has not only never been confirmed, but it has never been tested, because all the previous studies dealt only with the presence or absence instead of the frequency of positive selection. To provide evidence for or against different frequencies of positively selected CenH3 in asymmetrics and symmetrics, we have inferred the selective pressures acting on CenH3 in seventeen eukaryotic clades, including plants, animals, fungi, ci

SUBMITTER: Zedek F 

PROVIDER: S-EPMC5024113 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature