Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease.

ABSTRACT:

Background

We recently demonstrated a positive effect of berberine on nonalcoholic fatty liver disease patients after 16 weeks of treatment by comparing mere lifestyle intervention in type 2 diabetes patients with berberine treatment, which decreased the content of hepatic fat. However, the potential mechanisms of the clinical effects are unclear. We used a lipidomic approach to characterize the state of lipid metabolism as reflected in the circulation of subjects with nonalcoholic fatty liver disease (NAFLD) before and after berberine treatment.

Methods

Liquid chromatography-mass spectrometry evaluated the various lipid metabolites in serum samples obtained from the participants (41 patients in the berberine group and 39 patients in the mere lifestyle intervention group) be

SUBMITTER: Chang X 

PROVIDER: S-EPMC5024486 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature