Decoding the usefulness of non-coding RNAs as breast cancer markers.

ABSTRACT: Although important advances in the management of breast cancer (BC) have been recently accomplished, it still constitutes the leading cause of cancer death in women worldwide. BC is a heterogeneous and complex disease, making clinical prediction of outcome a very challenging task. In recent years, gene expression profiling emerged as a tool to assist in clinical decision, enabling the identification of genetic signatures that better predict prognosis and response to therapy. Nevertheless, translation to routine practice has been limited by economical and technical reasons and, thus, novel biomarkers, especially those requiring non-invasive or minimally invasive collection procedures, while retaining high sensitivity and specificity might represent a significant development in this field. A

SUBMITTER: Amorim M 

PROVIDER: S-EPMC5024523 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature