Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons.

ABSTRACT: In brain, signaling mediated by cell adhesion molecules defines the identity and functional properties of synapses. The specificity of presynaptic and postsynaptic interactions that is presumably mediated by cell adhesion molecules suggests that there exists a logic that could explain neuronal connectivity at the molecular level. Despite its importance, however, the nature of such logic is poorly understood, and even basic parameters, such as the number, identity, and single-cell expression profiles of candidate synaptic cell adhesion molecules, are not known. Here, we devised a comprehensive list of genes involved in cell adhesion, and used single-cell RNA sequencing (RNAseq) to analyze their expression in electrophysiologically defined interneurons and projection neurons. We compared the

SUBMITTER: Foldy C 

PROVIDER: S-EPMC5024636 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature